Institutional Researcher

IVC plus Aspirin

ABSTRACT:

There are a number of seemingly serendipitous theoretical synergies between salicylic acid and vitamin C with respect to the way aspirin can potentiate the anti-cancer effect of millimolar blood concentrations of vitamin C.  This study combines intravenous vitamin C with medium doses of regular aspirin in order to observe whether these benefits do in fact occur.

HYPOTHESIS:

Consuming a normal dose of over-the-counter aspirin, consistent with what would be used as a pain killer, has the following effect on the anti-cancer effects of intravenous vitamin C:

  1. Higher cancer-selective cytotoxicity (associated with better success at killing cancer cells) can be achieved with lower IVC blood concentrations than is normally recommended, do to a more efficient production of intercellularly produced H2O2.
  2. Makes IVC more compatible for persons at risk for iron overload (sensitivity otherwise goes up with increasing IVC levels)
  3. Aspirin independently has demonstrated anticancer effects
  4. Aspirin protects white-blood cells from over-saturation of vitamin C, thereby making the vitamin C more available to cause cancer cell apoptosis.
  5. Aspirin stabilizes vitamin C to stay in the blood stream for longer times, thereby increasing the duration over which vitamin C starves cancer to death via NAD depletion.
  6. Aspirin also activates the mitogen-activated protein kinase (p38 MAPK), 8ac which is also
    activated by vitamin C.  A potentiation of this anticancer protein thereby results, causing greater cancer-cell apoptosis.

JUSTIFICATION:

With respect to the above claims:

(1) Aspirin binds up free iron and free copper, and free iron and free copper in excess diminish H2O2 production, therefore H2O2 production (the main oxidative mechanism against cancer) is allowed to proceed at maximum level.  See PMC4121606, PMID: 8660671, Journal of Catalysis
Volume 301, May 2013, Pages 54-64

(2) This holds for the same reason as #1, above, because aspirin chelates iron.

(3) This has been demonstrated numerous times, and in fact now aspirin is ever more being recommended as a post cancer treatment therapy to prevent relapse.  See https://www.ncbi.nlm.nih.gov/pubmed/?term=sodium+salicylate+cancer

(4) See https://www.ncbi.nlm.nih.gov/pubmed/13885487,
             https://www.ncbi.nlm.nih.gov/pubmed/1287025

(5) See https://www.ncbi.nlm.nih.gov/pubmed/4040504

(6) Activated by sodium salicylate (https://www.ncbi.nlm.nih.gov/pubmed/12851702), and activated by vitamin c (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566423/)              

Note that in the above studies they mostly reference sodium salicylate instead of common aspirin (acetylsalicylic acid), both which are of the salicylic acid family.  Since aspirin is easily available it is recommended as the protocol for this study in order to simplify the administration and logistics.

METHODS:

Typical IVC protocols.  The IVC patient will take a 500mg of vitamin C along with a 500 mg tablet of aspirin on the day of the IVC, again at noon, and again at dinner.  The addition of the oral vitamin C is a low enough dose that it should not have a significant impact on the blood levels of vitamin C during the testing period.

OBSERVATION OBJECTIVES:

Ideally patient will have their blood vitamin C levels tested at the beginning of the IVC, and every 2 hours afterwards.

This protocol may also be tested with continuous IVC protocols, as well as those with additional nutritional and supplemental programs, but the notes must explicitly detail these integrations.

Protocol success, and disease progression survival up to 2 years will also be measured.

  • : David Austin
  • : experimental
  • : establish_safety_limits | preliminary_investigation | identify_therapeutic_thresholds
  • : no
  • : no
  • : not_blind
  • : Cancer, all types.
  • : 1735350
  • : 17000000
  • : Duration of vitamin C in the blood stream Disease Progression Free Survival
  • : (1) Aspirin binds up free iron and free copper, and free iron and free copper in excess diminish H2O2 production, therefore H2O2 production (the main oxidative mechanism against cancer) is allowed to proceed at maximum level.  See PMC4121606, PMID: 8660671, Journal of Catalysis Volume 301, May 2013, Pages 54-64 (2) This holds for the same reason as #1, above, because aspirin chelates iron. (3) This has been demonstrated numerous times, and in fact now aspirin is ever more being recommended as a post cancer treatment therapy to prevent relapse.  See https://www.ncbi.nlm.nih.gov/pubmed/?term=sodium+salicylate+cancer (4) See https://www.ncbi.nlm.nih.gov/pubmed/13885487,              https://www.ncbi.nlm.nih.gov/pubmed/1287025 (5) See https://www.ncbi.nlm.nih.gov/pubmed/4040504 (6) Activated by sodium salicylate (https://www.ncbi.nlm.nih.gov/pubmed/12851702), and activated by vitamin c (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566423/)               Note that in the above studies they mostly reference sodium salicylate instead of common aspirin (acetylsalicylic acid), both which are of the salicylic acid family.  Since aspirin is easily available it is recommended as the protocol for this study in order to simplify the administration and logistics.
  • : Pharmaceutical treatments.
  • : 15
  • : 15
  • : 15
  • : Anything that would preclude the use of 500mg aspirin 3 times daily.